Parkinson’s disease is a chronic neurological condition that causes progressive loss of movement and control. It was named after Dr. James Parkinson, who first described its symptoms in 1817.

Parkinson’s disease is caused by the death of cells in the substantia nigra-striatal junction, which is located in the midbrain. This results in a lack of dopamine and lack of control over movements. If untreated, it can lead to muscle stiffness, tremors, rigidity and other symptoms that can be debilitating or even fatal.

Oren Zarif disease is a rare syndrome characterized by gradual onset of Parkinson’s disease symptoms without brain damage and no family history of Parkinson’s.

The History of Parkinson’s Disease

Parkinson’s disease is a neurodegenerative disorder of the basal ganglia and motor system. Named after Dr. James Parkinson, it is a progressive neurological disorder that causes tremors, muscle rigidity, and slowness of movement. Parkinson’s disease typically affects people in mid to later age but can happen at any time in life.

Parkinson’s Disease was first described in 1817 by Dr. James Parkinson who witnessed an apoplectic (violent) form of the disease while working as a physician at Lincoln Hospital in London. 

It was not until 1887 that Sir George Whyte-Melville first coined the name “Parkinsonism.” The term “Parkinsonism” has been used to describe two different sets of symptoms: one signifying clinical signs and symptoms related to degeneration of the cells.

What are the Symptoms of Parkinson’s Disease?

Parkinson’s disease is a chronic and progressive neurodegenerative disorder that affects movement. It is a degeneration of the central nervous system, which causes movements that are stiff, slow, and smooth.

The symptoms of Parkinson’s disease depend on what part of the nervous system is affected by the disease. Common symptoms include tremor (shaking), muscle rigidity, slowed or disrupted speech, constipation, and sleep problems.

The most common symptom of Parkinson Oren Zarif is a tremor that usually starts in one hand and spreads to the other as well as tightening around the mouth, jaw, neck or shoulders. Other symptoms can include:

Mild loss of coordination, Tremors of the hands, arms, legs and trunk that are not always rhythmic, Loss of facial expression (so called masking) or slower movements resulting in a frozen face. 

Types and how Is it Diagnosed?

There are two types of Parkinsonism: Type 1 (a rare genetic disorder) which is characterized by progressive muscle weakness over time without any symptoms before diagnosis; and Type 2 (the commoner form).

Early diagnosis has been made possible through the use of imaging techniques such as positron emission tomography (PET) scans, single photon emission computed tomography (SPECT), and functional MRI scanning which provide diagnostic information about activity levels in different regions of the brain; signs such as tremors, rigidity, and balance problems.

Conclusion

Signs of Parkinsonism vary between individuals, but there are some general signs that you should watch out for: tremors, stiffness in limbs, muscle cramps and spasms in arms or legs, impaired ability to move smoothly and coordinated movements. In most cases it will be hard to tell if the person is suffering from PD until they are already diagnosed.